Electrical versus pharmacological cardioversion for emergency department patients with acute atrial fibrillation (RAFF2): a partial factorial randomised trial.
Stiell IG, et al. Lancet. 2020 Feb 1;395(10221):339-349
Question and Methods: This partial factorial randomized trial aimed to determine which rhythm control strategy was superior; procainamide followed by electrical cardioversion if needed compared with electrical cardioversion alone. It also sought to determine whether anterolateral or antero-posterior pad placement was superior.
Findings: There was no difference in the rate of conversion to sinus rhythm between the drug-shock and shock only groups which were both highly successful (96% and 92% respectively, p 0.066). There was also no significant difference in cardioversion rates based on pad placement.
Limitations: The only chemical cardioversion agent used was procainamide.
Interpretation: The evidence equally supports drug-shock and shock only strategies for achieving rhythm control in acute atrial fibrillation. For most patient’s, the drug-shock approach may be optimal given lower resource utilization.
By: Dr. Michael Hale