Methodology: 2/5
Usefulness: 2/5

van der Geest KSM, et al. JAMA Intern Med. 2020 Oct 1;180(10):1295-1304. 

Question and Methods: Systematic review and meta-analysis of 68 studies to identify clinical and laboratory findings that can help identify patients with GCA
Findings: No single clinical or laboratory feature were strong enough to confirm or refute the diagnosis of GCA alone
Limitations: There were several sources of bias from poor quality studies, lack of high-quality reference standards and substantial heterogeneity of index tests.

Interpretation: No change to practice. Combinations or absence of these signs/symptoms can assist in decision making to pursue further investigation +/- expedited referral.

By: Dr. Graham Wilson

Hans Rosenberg
Dr. Rosenberg is an emergency physician at the Ottawa Hospital, assistant professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.