Question and Methods: This single-center, RCT of 120 patients with acute renal colic compared pain control and antiemetic use with dexamethasone + ketorolac compared to ketorolac alone.
Findings: Significantly lower pain at 30 minutes (VAS 3.5 vs. 5), not at 60 minutes; significantly lower narcotic (35% vs 58%) and antiemetic use (7% vs 17%) at 60 minutes.
Limitations: Questionable patient inclusion criteria; lack of longer follow-up and other meaningful outcomes.
Interpretation: Further large-scale studies addressing the weaknesses and inclusion of important outcomes needed before adoption.
By: Dr. Marissa Ukos
Dr. Marissa Lai Sa Ukos MD
Dr. Rosenberg is an emergency physician at the Ottawa Hospital, associate professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.
Dr. Venkatesh Thiruganasambandamoorthy is an attending physician and associate scientist at the Ottawa Hospital and Ottawa Hospital Research Institute with an particular interest in syncope and presyncope care.