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Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab

by Joyes Botros, Jeff Perry, Hans Rosenberg | Apr 18, 2022 | COVID-19, Full Article, Infectious Disease, Journal Club, landmark, Public health

Methodology: 4/5 Usefulness: 4/5 Gupta A, et al. N Engl J Med. 2021 Nov 18;385(21):1941-1950. Question and Methods: COMET-ICE trial evaluated the efficacy and safety of sotrovimab in high-risk, mild-to-moderate Covid-19 not requiring oxygen, within 5 days of symptom...

Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial

by Kevin Durr, Jeff Perry, Hans Rosenberg | Jan 24, 2022 | Full Article, Infectious Disease, Journal Club

Methodology: 3.5/5 Usefulness: 3.5/5 COVID STEROID 2 Trial Group, Munch MW, et al. JAMA. 2021 Nov 9;326(18):1807-1817. doi: 10.1001/jama.2021.18295. Question and Methods: This blinded randomized clinical trial compared the effects of 12 mg daily relative to 6 mg daily...

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

by Hans Rosenberg | Jul 26, 2021 | Full Article, Infectious Disease, Journal Club, landmark, Public health

Methodology: 4/5 Usefulness: 4.5/5 Polack FP, et al. N Engl J Med. 2020 Dec 31;383(27):2603-2615. doi: 10.1056/NEJMoa2034577. Epub 2020 Dec 10. Editorial: SARS-CoV-2 Vaccination – An Ounce (Actually, Much Less) of Prevention. Question/methods: Multinational,...

Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.

by Hans Rosenberg | Jun 14, 2021 | COVID-19, Infectious Disease, Journal Club, Respirology

Methodology: 2.5/5 Usefulness: 2/5 Ramakrishnan S, et al. Lancet Respir Med. 2021 Apr 9:S2213-2600(21)00160-0. Question and Methods: Is inhaled budesonide an effective treatment for patients with mild early symptoms of COVID-19? A randomized, open-label clinical trial...

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis

by Hans Rosenberg | Apr 27, 2021 | COVID-19, Critical Care, Featured, Full Article, Infectious Disease, Journal Club

Methodology: 4/5 Usefulness: 4/5 WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne JAC et al. JAMA. 2020 Oct 6;324(13):1330-1341. Question and Methods: Prospective meta-analysis of 7 RCTs investigating the utility of systemic...