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Early versus Later Anticoagulation for Stroke with Atrial Fibrillation

by Josee Malette, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | May 20, 2024 | Full Article, Journal Club, Neurology

Methodology: 3/5 Usefulness: 2/5 Fischer U, et al. N Engl J Med. 2023 Jun 29;388(26):2411-2421. Question and Methods: RCT at 103 sites to compare outcomes at 30 days for early versus late DOAC initiation among patients with ischemic stroke and atrial fibrillation....

Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion

by Maria Berliant, Hans Rosenberg, Christian Vaillancourt | May 6, 2024 | Featured, Full Article, Journal Club, Neurology

Methodology: 4/5 Usefulness: 3/5 Zi W, et al. N Engl J Med. 2023 Jun 1;388(22):2025-2036. Editorial: Expanding Treatment for Acute Ischemic Stroke beyond Revascularization. Question and Methods: This multi-centre, triple-blind, double dummy RCT in China aimed to...

Posterior Circulation Strokes

by Kathleen O'Connell | Mar 14, 2024 | Critical Care, Featured, Grand Round Summaries, Neurology, Resuscitation

Posterior circulation ischemia accounts for approximately 20-25% of all ischemic strokes and is a significant cause of patient disability. The diagnosis can be extremely challenging as findings are often not typically focal. Posterior strokes are misdiagnosed more...

Early versus delayed antihypertensive treatment in patients with acute ischaemic stroke: multicentre, open label, randomised, controlled trial

by Pascale King, Hans Rosenberg, Christian Vaillancourt | Jan 2, 2024 | Critical Care, Full Article, Journal Club, Neurology

Methodology: 4/5 Usefulness: 2/5 Liu L, et al. BMJ. 2023 Oct 9;383:e076448. Question: Do early vs delayed blood pressure management in patients with mild-moderate acute ischemic strokes decrease death or dependency at 90 days? Methods: Randomization to early (24 hrs)...

Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

by Emma Ferguson, Hans Rosenberg, Ian Stiell | Sep 26, 2022 | Journal Club, Neurology

Methodology: 4.5/5 Usefulness: 5/5 Menon BK, et al. Lancet. 2022 Jul 16;400(10347):161-169. doi: 10.1016/S0140-6736(22)01054-6. Question and Methods: This multicentre, open label, randomized control trial at 22 primary and comprehensive stroke centres across Canada...