epi lesson Archives

Short-term vs Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Obstructive Pulmonary Disease The REDUCE Randomized Clinical Trial

by emottawa | Sep 30, 2014 | Journal Club

Journal Club Summary Methodology Score: 4/5 Usefulness Score: 4/5 Leuppi JD, et al. JAMA. 2013 Jun 5;309(21):2223-31. Article Link This multicenter, double blinded trial demonstrated non-inferiority of a 5-day course of 40mg prednisone versus a...

Albumin replacement in patients with severe sepsis or septic shock

by emottawa | Sep 22, 2014 | Journal Club

Journal Club Summary Methodology Score: 3.5/5 Usefulness Score: 2.5/5 Caironi P, Tognoni G, et al. the ALBIOS Study Investigators. N Engl J Med. 2014 Mar 18. Abstract Link This was an open-label RCT of 1,800 ICU patients with severe sepsis or septic...

Accuracy of single progesterone test to predict early pregnancy outcome in women with pain or bleeding: meta-analysis of cohort studies

by emottawa | Sep 15, 2014 | Journal Club

Journal Club Summary Methodology Score: 4/5 Usefulness Score: 2/5 Verhaegen J, Gallos ID, van Mello NM, Abdel-Aziz M, Takwoingi Y, Harb H, Deeks JJ, Mol BW, Coomarasamy A BMJ. 2012 Sep 27;345:e6077 Article Link This thorough and well performed...

Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trial

by emottawa | Sep 8, 2014 | Journal Club

Journal Club Summary Methodology Score: 4/5 Usefulness Score: 3.5/5 Aujesky D, et al. Lancet. 2011 Jul 2;378(9785):41-8. Abstract Link This open label, randomized, un-blinded, multi-centered trial compared inpatient vs. outpatient treatment of low-risk PE showed...

Fever Control Using External Cooling in Septic Shock: A Randomized Controlled Trial

by emottawa | Sep 1, 2014 | Journal Club

Journal Club Summary Methodology Score: 2.5/5 Usefulness Score: 2/5 Schortgen F, et al. Am J Respir Crit Care Med. 2012 May 15;185(10):1088-95 Full Article This randomized, non-blinded trial found in an ICU population that external cooling in...