Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.
Methodology: 2.5/5 Usefulness: 2/5 Ramakrishnan S, et al. Lancet Respir Med. 2021 Apr 9:S2213-2600(21)00160-0. Question and Methods: Is inhaled budesonide an effective treatment for patients with mild early symptoms of COVID-19? A randomized, open-label clinical trial...
Ottawa Handbook of Emergency Medicine
The Ottawa Handbook of Emergency Medicine is a peer-reviewed resource designed to help you succeed in the Emergency Department. Developed for clerkship students, junior residents, off-service learners, nurses, paramedics and any other interested allied health...
Implementation of an ED ECMO Program
In the first part of this series, we looked at the basics of Extra Corporeal Membrane Oxygenation (ECMO) and its primary indications. In this section, we will discuss the factors that are needed to implement an ED ECMO program and what happens when a code ECPR is...
Thrombolytics redux! A rebuttal
Hey everyone! Buckle up. This is a long one. To provide context, I recently presented a 2-part blog post regarding thrombolytics in acute ischemic stroke. In these posts I explored the foundational literature for this tPA, as well as some of the common controversies I...
Development and Validation of a Penicillin Allergy Clinical Decision Rule
Methodology: 3/5 Usefulness: 2/5 Trubiano JA, et al. JAMA Intern Med. 2020 May 1;180(5):745-752. Question and Methods: Prospective derivation and subsequent retrospective validation of a clinical decision rule for the detection of patients at low risk for true...
#CAEP21 – CAEP at the Forks: Rising to the Challenge
Hey everyone! Are you an emergency medicine provider? Whether you are a seasoned attending or interested medical student there is something for you at #CAEP21. The annual meeting of the Canadian Association of Emergency Physicians (CAEP) is happening virtually on June...
Are We Ready for ECMO on the Ground Floor?
Extra Corporeal Membrane Oxygenation (ECMO) has significantly progressed over the past decades. It has become an invaluable tool in the care of adults with severe cardiac and pulmonary disease refractory to conventional management. The implementation of ECMO has even...
Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms
Methodology: 3/5 Usefulness: 3/5 Couturaud F, et al. JAMA. 2021 Jan 5;325(1):59-68. Question and Methods: This study used a multicenter, cross-sectional methodology with prospective follow up to determine the rates of PE in 740 COPD patients using the rGeneva score....
Thrombolytic Therapy: A Stroke of Luck? Part 2
Addressing the Controversies Around Thrombolytic Therapy (tPA) In our previous blog post, we reviewed the formative literature supporting the currently used tPA time window. The figure below highlights a summary of the time windows investigated within each study and...
Thrombolytic Therapy: A Stroke of Luck? Part 1
Review of the formative literature of our current tPA time window in Acute Ischemic Stroke After numerous case series and smaller prospective studies suggesting benefit for thrombolytic therapy (tPA), the early 90s ushered in the era of thrombolytic RCTs for acute...