by Hans Rosenberg | Jun 14, 2021 | COVID-19, Infectious Disease, Journal Club, Respirology
Methodology: 2.5/5 Usefulness: 2/5 Ramakrishnan S, et al. Lancet Respir Med. 2021 Apr 9:S2213-2600(21)00160-0. Question and Methods: Is inhaled budesonide an effective treatment for patients with mild early symptoms of COVID-19? A randomized, open-label clinical trial...
by Doran Drew | Jun 8, 2021 | Commentary, Critical Care, Grand Round Summaries, Journal Club, Neurology, Resuscitation
Hey everyone! Buckle up. This is a long one. To provide context, I recently presented a 2-part blog post regarding thrombolytics in acute ischemic stroke. In these posts I explored the foundational literature for this tPA, as well as some of the common controversies I...
by Hans Rosenberg | Jun 7, 2021 | Featured, Immunology, Infectious Disease, Journal Club
Methodology: 3/5 Usefulness: 2/5 Trubiano JA, et al. JAMA Intern Med. 2020 May 1;180(5):745-752. Question and Methods: Prospective derivation and subsequent retrospective validation of a clinical decision rule for the detection of patients at low risk for true...
by Hans Rosenberg | May 31, 2021 | Journal Club, Respirology, Thrombosis
Methodology: 3/5 Usefulness: 3/5 Couturaud F, et al. JAMA. 2021 Jan 5;325(1):59-68. Question and Methods: This study used a multicenter, cross-sectional methodology with prospective follow up to determine the rates of PE in 740 COPD patients using the rGeneva score....
by Hans Rosenberg | May 10, 2021 | ENT, Featured, Journal Club, Thrombosis
Methodology: 3/5 Usefulness: 3/5 Reuben A, et al. Ann Emerg Med. 2021 Feb 18:S0196-0644(20)31461-X. Question and Methods: This was a double-blind, randomized controlled trial comparing topical tranexamic acid to placebo in patients presenting to the ED with epistaxis...
by Hans Rosenberg | May 3, 2021 | Featured, Full Article, Journal Club, Ophthalmology
Methodology: 2/5 Usefulness: 2/5 Shipman S, et al. Ann Emerg Med. 2021 Mar;77(3):338-344. doi: 10.1016/j.annemergmed.2020.08.036. Question and Methods: Double blinded RCT comparing tetracaine versus placebo eye drops for 24 hours in the treatment of pain...
by Hans Rosenberg | Apr 27, 2021 | COVID-19, Critical Care, Featured, Full Article, Infectious Disease, Journal Club
Methodology: 4/5 Usefulness: 4/5 WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne JAC et al. JAMA. 2020 Oct 6;324(13):1330-1341. Question and Methods: Prospective meta-analysis of 7 RCTs investigating the utility of systemic...
by Hans Rosenberg | Apr 5, 2021 | Journal Club, Nephrology
Methodology: 3.5/5 Usefulness: 2/5 Gaudry S, et al. Lancet. 2020 May 9;395(10235):1506-1515. Question and Methods: Gaudry et al performed a systematic review and individual patient data meta-analysis of randomized control trials to compare the benefits of early versus...
by Hans Rosenberg | Mar 29, 2021 | Full Article, Journal Club, Rheumatology
Methodology: 2/5 Usefulness: 2/5 van der Geest KSM, et al. JAMA Intern Med. 2020 Oct 1;180(10):1295-1304. Question and Methods: Systematic review and meta-analysis of 68 studies to identify clinical and laboratory findings that can help identify patients with GCA...
by Hans Rosenberg | Mar 22, 2021 | Journal Club, Neurology
Methodology: 4/5 Usefulness: 3.5/5 Thomalla G, et al. Lancet. 2020 Nov 14;396(10262):1574-1584 Question and Methods: The authors evaluated the role of perfusion-imaging facilitated thrombolysis in strokes of unknown duration by way of a systematic review and...
