Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials

Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials

Methodology: 3.5/5 Usefulness: 2/5 Gaudry S, et al. Lancet. 2020 May 9;395(10235):1506-1515. Question and Methods: Gaudry et al performed a systematic review and individual patient data meta-analysis of randomized control trials to compare the benefits of early versus...
Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial

Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial

Methodology: 3.5/5 Usefulness: 3.5/5 Yannopoulos D, et al. Lancet. 2020 Dec 5;396(10265):1807-1816. Question and Methods: The ARREST trial was a phase 2, single centre, open-label, RCT comparing early ECMO facilitated resuscitation to ED-based standard ACLS care for...
Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial

Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial

Methodology: 4.5/5 Usefulness: 4/5 Schuh S, et al. JAMA. 2020 Nov 24;324(20):2038-2047. Question and Methods: RCT assessing the effectiveness of nebulized magnesium versus placebo in children presenting with an acute asthma exacerbation refractory to standard therapy,...
Plaster cast versus functional brace for non-surgical treatment of Achilles tendon rupture (UKSTAR): a multicentre randomised controlled trial and economic evaluation

Plaster cast versus functional brace for non-surgical treatment of Achilles tendon rupture (UKSTAR): a multicentre randomised controlled trial and economic evaluation

Methodology: 3.5/5 Usefulness: 3.5/5 Costa ML et al. Lancet. 2020 Feb 8;395(10222):441-448. Question and Methods: The UKSTAR trial was a pragmatic, multicenter RCT that compared plaster cast against walking boot for non-operative management of Achilles tendon rupture...