by Hans Rosenberg | Jul 26, 2021 | Full Article, Infectious Disease, Journal Club, landmark, Public health
Methodology: 4/5 Usefulness: 4.5/5 Polack FP, et al. N Engl J Med. 2020 Dec 31;383(27):2603-2615. doi: 10.1056/NEJMoa2034577. Epub 2020 Dec 10. Editorial: SARS-CoV-2 Vaccination – An Ounce (Actually, Much Less) of Prevention. Question/methods: Multinational,...
by Hans Rosenberg | Jul 19, 2021 | Infectious Disease, Journal Club, Pediatrics
Methodology: 3/5 Usefulness: 1/5 Mas-Dalmau G, et al. Pediatrics. 2021 Mar;147(3):e20201323. doi: 10.1542/peds.2020-1323. Question and Methods: This RCT assessed effectiveness and safety of delayed (DAP), immediate (IAP) and no antibiotic prescription (NAP) in...
by Hans Rosenberg | Jul 8, 2021 | Journal Club, Thrombosis
Methodology: 3.5/5 Usefulness: 2/5 Xu K, et al. J Thromb Haemost. 2021 Apr 8. doi: 10.1111/jth.15337. Epub ahead of print. PMID: 33834620. Question and methods: The authors sought to develop a new, simplified clinical decision rule to exclude DVT using individual...
by Hans Rosenberg | Jun 14, 2021 | COVID-19, Infectious Disease, Journal Club, Respirology
Methodology: 2.5/5 Usefulness: 2/5 Ramakrishnan S, et al. Lancet Respir Med. 2021 Apr 9:S2213-2600(21)00160-0. Question and Methods: Is inhaled budesonide an effective treatment for patients with mild early symptoms of COVID-19? A randomized, open-label clinical trial...
by Doran Drew | Jun 8, 2021 | Commentary, Critical Care, Grand Round Summaries, Journal Club, Neurology, Resuscitation
Hey everyone! Buckle up. This is a long one. To provide context, I recently presented a 2-part blog post regarding thrombolytics in acute ischemic stroke. In these posts I explored the foundational literature for this tPA, as well as some of the common controversies I...
by Hans Rosenberg | Jun 7, 2021 | Featured, Immunology, Infectious Disease, Journal Club
Methodology: 3/5 Usefulness: 2/5 Trubiano JA, et al. JAMA Intern Med. 2020 May 1;180(5):745-752. Question and Methods: Prospective derivation and subsequent retrospective validation of a clinical decision rule for the detection of patients at low risk for true...
by Hans Rosenberg | May 31, 2021 | Journal Club, Respirology, Thrombosis
Methodology: 3/5 Usefulness: 3/5 Couturaud F, et al. JAMA. 2021 Jan 5;325(1):59-68. Question and Methods: This study used a multicenter, cross-sectional methodology with prospective follow up to determine the rates of PE in 740 COPD patients using the rGeneva score....
by Hans Rosenberg | May 10, 2021 | ENT, Featured, Journal Club, Thrombosis
Methodology: 3/5 Usefulness: 3/5 Reuben A, et al. Ann Emerg Med. 2021 Feb 18:S0196-0644(20)31461-X. Question and Methods: This was a double-blind, randomized controlled trial comparing topical tranexamic acid to placebo in patients presenting to the ED with epistaxis...
by Hans Rosenberg | May 3, 2021 | Featured, Full Article, Journal Club, Ophthalmology
Methodology: 2/5 Usefulness: 2/5 Shipman S, et al. Ann Emerg Med. 2021 Mar;77(3):338-344. doi: 10.1016/j.annemergmed.2020.08.036. Question and Methods: Double blinded RCT comparing tetracaine versus placebo eye drops for 24 hours in the treatment of pain...
by Hans Rosenberg | Apr 27, 2021 | COVID-19, Critical Care, Featured, Full Article, Infectious Disease, Journal Club
Methodology: 4/5 Usefulness: 4/5 WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne JAC et al. JAMA. 2020 Oct 6;324(13):1330-1341. Question and Methods: Prospective meta-analysis of 7 RCTs investigating the utility of systemic...
