Stroke Archives

Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature

by emottawa | Mar 17, 2014 | Journal Club

Journal Club Summary Methodology Score: 4.5/5 Usefulness Score: 3/5 Dentali F, Riva N, Crowther M, Turpie AG, Lip GY, Ageno W. Circulation. 2012 Nov 13;126(20):2381-91. Article Link This was a systematic review and meta-analysis of 12 phase II/III...

The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial

by emottawa | Jan 29, 2013 | Journal Club

Journal Club Summary Methodology: 2.5/5 Usefulness: 2.5/5 IST-3 collaborative group, Sandercock P, Wardlaw JM, et al. Lancet. 2012 Jun 23;379(9834):2352-63. Article Link This international, multicenter, randomized, open-treatment trial was aimed at detecting...

A randomized trial of tenecteplase versus alteplase for acute ischemic stroke

by emottawa | Jan 14, 2013 | Journal Club

Journal Club Summary Methodology: 3/5 Usefulness: 3/5 Parsons M, Spratt N, Bivard A, Campbell B, Chung K, Miteff F, O’Brien B, Bladin C, McElduff P, Allen C, Bateman G, Donnan G, Davis S, Levi C. N Engl J Med. 2012 Mar 22;366(12):1099-107....

Prospective validation of the ABCD2 score for patients in the emergency department with transient ischemic attack

by emottawa | Dec 15, 2012 | Journal Club

Journal Club Summary Landmark Series Methodology Score: 4/5 Usefulness Score: 4/5 Perry JJ, Sharma M, Sivilotti ML, Sutherland J, Symington C, Worster A, Émond M, Stotts G, Jin AY, Oczkowski WJ, Sahlas DJ, Murray HE, MacKey A, Verreault...

Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials

by EMOttawa | Jul 9, 2012 | Journal Club, landmark

Journal Club Summary Methodology: 4/5 Usefulness: 4.5/5 Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, Albers GW, Kaste M, Marler JR, Hamilton SA, Tilley BC, Davis SM, Donnan GA, Hacke W; ECASS, ATLANTIS, NINDS and EPITHET rt-PA Study Group, Allen...