Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S; Emergency Medicine Shock Research Network (EMShockNet) Investigators. JAMA 2010 Jun 2;303(21):2165-71.
This is the first study to use clinical data to establish an association between post-ROSC hyperoxia and increased in-hospital mortality in non-traumatic post-cardiac arrest patients (OR 1.8, CI 1.5-2.2) using multi-centre retrospective cohort data from a US ICU database. There were considerable potential confounders that limit the validity of this study’s results (including CPR data, timing of ABG collection, etc); however, this was a landmark study since it suggested an association between hyperoxia & mortality and will likely prompt further research into modifiable post-ROSC mortality risk factors.
By Dr. Aseem Bishnoi