Jalili M, Fathi M, Moradi-Lakeh M, Zehtabchi S.
Ann Emerg Med. 2012 Apr;59(4):276-80.
This double blind, double dummy RCT compared sublingual Buprenorphine (0.4 mg) to IV Morphine (5 mg) for acute pain in adults presenting to the ED with acute fractures and found similar efficacy and side effects. While this was the first RCT to look at the use of SL Buprenorphine in the ED, numerous methodological weaknesses and small sample size precluded the ability to infer any equivalence to IV morphine in this population.
By Dr. Laura Francis