Journal Club Summaryhydrocortisone


Landmark Series

Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, et al. N Engl J Med. 2008 Jan.10;358(2):111–24. 

Article Link


This European multicentre RCT compa
red hydrocortisone to placebo for 499 ICU patients with septic shock and found no difference in mortality despite quicker resolution of shock with hydrocortisone; the hydrocortisone patients had more episodes of superinfection including new sepsis. This landmark trial suggests no advantage and possible harm from routine use of hydrocortisone for septic shock.