Journal Club Summary

Methodology Score: 3.5/5
Usefulness Score: 4/5

De Backer D, Aldecoa C, Njimi H, Vincent JL. Crit Care Med. 2012 Mar;40(3):725-30.
Article Link

This meta-analysis of 6 trials found that in patients with septic shock, dopamine administration was associated with greater mortality (RR 1.12, 95% CI 1.01-1.20; P=0.035) and a higher incidence of arrhythmic events (RR 2.34) compared to norepinephrine administration. The analysis was dominated by one large but negative trial by the same author and JC attendees were split as to whether norepinephrine should replace dopamine for septic shock.
By: Dr. Debra Eagles