Journal Club Summary
Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA; CHEST Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group. N Engl J Med. 2012 Nov 15;367(20):1901-11.
Pub Med Link
This blinded, multi-center, randomized, controlled trial compared 6% Hydroxyethyl starch (HES) (Voluven) versus normal saline for fluid resuscitation in 7,000 intensive care patients and found no difference in mortality but that use of HES was associated with a higher incidence of renal failure requiring dialysis. The methodology was well done and the findings are applicable to emergency medicine; however, our consensus was that there is no reason to use HES for volume resuscitation in critically ill patients.
By: Dr. Michael Hickey