Journal Club Summary Hydroxyethyl starch

Methodology: 4/5
Usefulness: 3.5/5

Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA; CHEST Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group. N Engl J Med. 2012 Nov 15;367(20):1901-11.
Pub Med Link
This blinded, multi-center, randomized, controlled trial compared 6% Hydroxyethyl starch (HES) (Voluven) versus normal saline for fluid resuscitation in 7,000 intensive care patients and found no difference in mortality but that use of HES was associated with a higher incidence of renal failure requiring dialysis. The methodology was well done and the findings are applicable to emergency medicine; however, our consensus was that there is no reason to use HES for volume resuscitation in critically ill patients. 
By: Dr. Michael Hickey
(Presented Nov/12)