Methodology Score: 4/5
Usefulness Score: 2/5
N Engl J Med. 2013 Jun 20;368(25):2355-65.
This large multicentre, partially blinded RCT compared aggressively lowering SBP to <140 vs. standard care in acute non-traumatic intracerebral hemorrhage and found no significant difference in rates of death or major disability between the two groups, although their secondary outcome was statistically significant for a improved functional outcomes in the study group. The overall opinion of our group was that this study will not change practice patterns.
By: Dr. Sebastian Dewhirst
(Presented Feb 2014)
Investigators and editors developed the CONSORT Statement (revised 2010 ) to improve the reporting of randomized controlled trials (RCTs) by means of a checklist and flow diagram. The flow diagram is intended to depict the passage of participants through an RCT and depicts numbers and explanations from four stages of a trial (enrollment, intervention allocation, follow-up, and analysis). The diagram explicitly shows the number of participants, for each intervention group, included in the primary data analysis.
By: Dr. Ian Stiell