Journal Club Summary
Landmark Series
Methodology Score: 4/5
Usefulness Score: 5/5
ARISE Investigators and the ANZICS Clinical Trials Group. N Engl J Med. 2014 Oct 16;371(16):1496-506
ARISE was a multicenter, international ED unblinded RCT that found no difference in all-cause 90 day mortality (ARR 0.3%, NNT 352), and no difference in multiple clinically-important secondary outcomes, between modern day non-protocolized septic shock management and the Early Goal Directed Therapy (EGDT) protocol. In conjunction with ProCESS, this is a landmark study emphasizing that the key components of the EGDT protocol to optimize septic shock management are early recognition, early antibiotics, and optimal fluid resuscitation.
By: Dr. Aseem Bishnoi
(Presented November 2014)
Epi lesson: Survival Analyses
Survival analyses are used in clinical trials that follow patients over time for primary outcomes such as death, relapse, adverse drug reaction, or development of a new disease. The follow-up time may range from hours to years and a different set of statistical procedures are employed to analyze the data. Terms frequently seen in papers with survival analyses include Cox proportional hazard model, hazard ratio, Kaplan-Meir curve.
By: Dr. Ian Stiell
