Journal Club Summary
It is not uncommon for a manuscript to report several secondary outcomes. The number of secondary comparisons is directly proportional to the chance that one of them will end-up being statistically significant by chance alone. To account for this, statisticians should make it proportionally more difficult to find such a statistical difference. The Bonferroni correction suggests that the level of significance (alpha error, 0.05) should be divided by the number of comparisons made i.e. 0.05/5 comparisons = new alpha of 0.01.