Journal Club Summary
Methodology Score: 3.5/5
Usefulness Score: 3.5/5
Question and Methods: This meta-analysis included prospective studies to assess the ability of a single negative hs-cTnT and non-ischemic ECG to identify patients at low risk for AMI.
Findings: The results of 11 studies were pooled, resulting in a pooled sensitivity of 98.7% (95% CI 96.6-99.5%) No low-risk patients died.
Limitations: High risk of bias; heterogeneity; 7 potential eligible articles excluded;
Interpretation: A single negative hs-cTnT, non-ischemic ECG and reassuring clinical gestalt could potentially be used to safely discharge patients. It might lead to increased admission rate/cardiology consultations.
The Single High-Sensitivity Serum Cardiac Troponin T Level: A Significant Advance for Chest Pain Pathways? Kussmaul Iii WG. Ann Intern Med. 2017 May 16;166(10):751.
Meta-analysis of individual-patient data can have statistical and clinical advantages over the use of reported aggregate results. For e.g., aggregate results may be missing measures of spread, be subject to publication bias, or be presented differently between studies (e.g. OR vs. RR). Access to individual-patient data may help standardization of analyses across studies, provide access to more outcomes, and possibly lead to more reliable/different results compared to aggregate-data meta-analyses.