Methodology Score: 3/5
Usefulness Score: 3/5
Question/Methods: This study was done to determine the effectiveness of early prophylactic hypothermia compared with normothermic management of patients after severe traumatic brain injury (TBI).
Findings: No statistically significant difference in favorable neurologic outcomes at 6 months was found between the hypothermic and normothermic groups (48.8% vs 49.1%, respectively; (p=0.94)).
Major Limitations: A significant number of patients in the hypothermia group never reached the target temperature
Interpretation: This paper does not support the use of prophylactic hypothermia over normothermia in patients with TBI, and therefore should not change our current practice.
By: Dr. Maeghan Fu