Thiruganasambandamoorthy V, et al. Ann Intern Med. 2020 May 19;172(10):648-655.
Methods: Prospective cohort study to evaluate whether adding NT-proBNP to the CSRS improves prediction of 30-day SAEs.
Findings: Adding NT-proBNP provided no additional benefit to the model and would result in 10% of patients being correctly reclassified and 8.7% of patients being incorrectly reclassified in terms of risk.
Limitations: Possible selection bias, study powered to only detect 3% difference in AUC, small number of patients with SAEs in subgroups.
Interpretation: There is no current role for adding NT-proBNP to the ED work-up of syncope; CSRS alone has high predictive performance for 30-day SAEs.
By: Dr. Simon Wells