Methodology: 4/5
Usefulness: 3/5

Thiruganasambandamoorthy V, et al. Ann Intern Med. 2020 May 19;172(10):648-655.

Methods: Prospective cohort study to evaluate whether adding NT-proBNP to the CSRS improves prediction of 30-day SAEs.

Findings: Adding NT-proBNP provided no additional benefit to the model and would result in 10% of patients being correctly reclassified and 8.7% of patients being incorrectly reclassified in terms of risk.

Limitations: Possible selection bias, study powered to only detect 3% difference in AUC, small number of patients with SAEs in subgroups.

Interpretation: There is no current role for adding NT-proBNP to the ED work-up of syncope; CSRS alone has high predictive performance for 30-day SAEs.

By: Dr.  Simon Wells


  • Hans Rosenberg

    Dr. Rosenberg is an emergency physician at the Ottawa Hospital, assistant professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.