Methodology: 3/5
Usefulness: 2/5

Anton RF, et al. JAMA Intern Med. 2020 Mar 9;180(5):1-9. 

Question and Methods: Blinded randomized control trial comparing gabapentin to placebo in reducing the number of heavy drinking days in alcohol use disorder treatment.

Findings: They found fewer heavy drinking days and more abstinent days with gabapentin, but the effect was seen only in the subgroup with greater alcohol withdrawal symptoms.

Limitations: The main limitations were the highly selected sample and high drop-out rate.

Interpretation: The results suggest gabapentin may be beneficial in treating alcohol use disorder, but cannot be directly applied to a typical ED population or those in acute withdrawal.

By: Dr. Mark McKinney

Hans Rosenberg
Dr. Rosenberg is an emergency physician at the Ottawa Hospital, assistant professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.