Methodology: 2/5
Usefulness: 2/5

Jaung R, et al. Clin Gastroenterol Hepatol. 2020 Mar 30:S1542-3565(20)30426-2.

Question and Methods: This study investigated non-inferiority of placebo vs antibiotic in management of uncomplicated diverticulitis by conducting an international, multicenter, placebo-controlled, double blind RCT.
Findings: Hospital length of stay was “not inferior” in the placebo (45.8 hrs) compared to the antibiotic (40.0 hrs) group and secondary outcomes were similar.
Limitations: The major limitations are the inclusion criteria in this study and the primary outcome choice of length of stay rather than more clinically relevant outcomes.

Interpretation: We will likely continue using antibiotics for uncomplicated diverticulitis. However, this adds to the increasing evidence supporting selective antibiotics use with shared decision making.

By: Dr. Chirag Bhat

Hans Rosenberg
Dr. Rosenberg is an emergency physician at the Ottawa Hospital, assistant professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.