Methodology: 4/5
Usefulness: 1/5

Poonai N, et al. CMAJ. 2020 Nov 30;192(48):E1612-E1619.

Question and Methods: Randomized control trial assessing effect of hyoscine butylbromide (HBB) vs acetaminophen in nonspecific colicky pain in pediatric patients aged 8-17yo.

Findings: HBB produced >30mm reduction on the visual analogue pain scale in 45% of participants, and acetaminophen in 45.7%, at 80 minutes from time of administration. This study had some major limitations

Limitations: a small sample size, no placebo arm (as ethics did not approve this), and robust exclusion criteria greatly limiting generalizability.

Interpretation: This paper will likely not change practice for the majority of EM staff.

By: Dr. Tetyana Maniuk

Hans Rosenberg
Dr. Rosenberg is an emergency physician at the Ottawa Hospital, assistant professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.