Methodology: 4/5
Usefulness: 1/5

Poonai N, et al. CMAJ. 2020 Nov 30;192(48):E1612-E1619.

Question and Methods: Randomized control trial assessing effect of hyoscine butylbromide (HBB) vs acetaminophen in nonspecific colicky pain in pediatric patients aged 8-17yo.

Findings: HBB produced >30mm reduction on the visual analogue pain scale in 45% of participants, and acetaminophen in 45.7%, at 80 minutes from time of administration. This study had some major limitations

Limitations: a small sample size, no placebo arm (as ethics did not approve this), and robust exclusion criteria greatly limiting generalizability.

Interpretation: This paper will likely not change practice for the majority of EM staff.

By: Dr. Tetyana Maniuk


  • Dr. Rosenberg is an emergency physician at the Ottawa Hospital, assistant professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.