Methodology: 4/5
Usefulness: 3/5

Chu JJ, et al. Lancet. 2020 Sep 12;396(10253):770-778.

Editorial: Medical management of miscarriage with mifepristone

Question and Methods: This multi-centre, randomized, double blind, placebo-controlled trial compares spontaneous passage of gestational sac in patients with US-confirmed missed miscarriage when treated with mifepristone + misoprostol or placebo + misoprostol.

Findings: The primary outcome of failure to pass gestational sac within 7 days was 17% in mifepristone + misoprostol versus 24% in placebo + misoprostol. ARR = 6.6% and NNT = 15.

Limitations: Regulatory burdens in Ontario mean that the treatment is only covered for medical abortions and the use for missed miscarriage is costly to patients at $337 for patients.

Interpretation: This large RCT shows a significant reduction in failure to pass gestational sac when treated with mifepristone + misoprostol for missed miscarriage up to 14 weeks gestation compared to misoprostol alone. It adds to the body of evidence that this is a safe and effective treatment with missed miscarriage.

By: Dr. Emma Ferguson


  • Hans Rosenberg

    Dr. Rosenberg is an emergency physician at the Ottawa Hospital, assistant professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.