Mas-Dalmau G, et al. Pediatrics. 2021 Mar;147(3):e20201323. doi: 10.1542/peds.2020-1323.
Question and Methods: This RCT assessed effectiveness and safety of delayed (DAP), immediate (IAP) and no antibiotic prescription (NAP) in children presenting to primary care pediatricians with uncomplicated respiratory infections .
Findings: 436 children were included. The mean duration in days of severe symptoms was 10.01 for IAP, 10.9 for NAP and 12.5 for DAP (p=0.539).
Limitations: The study was conducted among primary pediatricians in Spain, outcomes were assessed
Interpretation: There is no real benefit of IAP vs. DAP vs. NAP in children who present with RTIs. Therefore, antibiotics should be withheld if safe.