Methodology: 3/5
Usefulness: 1/5

Mas-Dalmau G, et al. Pediatrics. 2021 Mar;147(3):e20201323. doi: 10.1542/peds.2020-1323.

Question and Methods: This RCT assessed effectiveness and safety of delayed (DAP), immediate (IAP) and no antibiotic prescription (NAP) in children presenting to primary care pediatricians with uncomplicated respiratory infections .  
Findings: 436 children were included. The mean duration in days of severe symptoms was 10.01 for IAP, 10.9 for NAP and 12.5 for DAP (p=0.539).  
Limitations: The study was conducted among primary pediatricians in Spain, outcomes were assessed

Interpretation: There is no real benefit of IAP vs. DAP vs. NAP in children who present with RTIs. Therefore, antibiotics should be withheld if safe.  

By: Dr. Rosa Ramaekers

Hans Rosenberg
Dr. Rosenberg is an emergency physician at the Ottawa Hospital, assistant professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.