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Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial

by emottawa | Jul 28, 2014 | Journal Club

Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 2/5   Bateman DN, et al. Lancet. 2014 Feb 22;383(9918):697-704 Article Link   This 2×2 factorial, intention to treat, randomized controlled trial of paracetamol overdose showed a...

Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage

by emottawa | Jul 21, 2014 | Journal Club

Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 2/5   INTERACT2 Investigators. N Engl J Med. 2013 Jun 20;368(25):2355-65.   Article Link   This large multicentre, partially blinded RCT compared aggressively lowering SBP to <140 vs....

Efficacy of pain control with topical lidocaine–epinephrine–tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial

by emottawa | Jul 14, 2014 | Journal Club

Journal Club Summary Methodology Score: 4.5/5                  Usefulness Score: 3.5/5 Harman S, Zemek R, Duncan MJ, Ying Y, Petrcich W. CMAJ. 2013 Sep 17;185(13):E629-34.   Article Link   This study was a double blind RCT which demonstrated that using topical LET on...

Bedside focused echocardiography as predictor of survival in cardiac arrest patients: a systematic review.

by emottawa | Apr 21, 2014 | Journal Club

Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 4/5   Blyth L, Atkinson P, Gadd K, Lang E. Acad Emerg Med. 2012 Oct;19(10):1119-26. Article Link   This systematic review of 8 studies found that when transthoracic ultrasound is performed...

Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.

by emottawa | Apr 14, 2014 | Journal Club

Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 2/5   Morelli A, et al. JAMA. 2013 Oct 23;310(16):1683-91 Article Link   This single centre phase 2B trial randomized septic patients still requiring vasopressors after 24hrs of EGDT to...

Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: prospective cohort study.

by emottawa | Apr 7, 2014 | Journal Club

Journal Club Summary Methodology Score: 3/5                  Usefulness Score: 2.5/5   Geersing GJ, et al. BMJ. 2012 Oct 4;345:e6564. Article Link   This was a prospective cohort validation study using the Wells clinical decision rule combined with D-dimer to exclude...

Targeted temperature management at 33°C versus 36°C after cardiac arrest

by emottawa | Mar 31, 2014 | Journal Club

Journal Club Summary Landmark Article Series Nielsen N, et al.; TTM Trial Investigators. N Engl J Med. 2013 Dec 5;369(23):2197-206.   Methodology Score: 5/5                             Usefulness Score: 5/5   Article Link   In this multicenter, international RCT of...

Clopridogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack

by emottawa | Mar 24, 2014 | Journal Club

Journal Club Summary Methodology Score: 4 /5                 Usefulness Score: 3.5/5   Wang Y, Johnston SC, Wang Y. N Engl J Med. 2013 Oct 3;369(14):1376-7. Article Link     This multicenter randomized-control trial of 5,100 patients with TIA/minor stroke treated...

Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature

by emottawa | Mar 17, 2014 | Journal Club

Journal Club Summary Methodology Score: 4.5/5              Usefulness Score: 3/5   Dentali F, Riva N, Crowther M, Turpie AG, Lip GY, Ageno W. Circulation. 2012 Nov 13;126(20):2381-91. Article Link   This was a systematic review and meta-analysis of 12 phase II/III...

A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial

by emottawa | Mar 10, 2014 | Journal Club

Journal Club Summary Methodology Score: 2/5                  Usefulness Score: 3.5/5 Zahed R, Moharamzadeh P, Alizadeharasi S, Ghasemi A, Saeedi M.Am J Emerg Med.2013 Sep;31(9):1389-92 Abstract Link This single centre, ED based, parallel group randomized control trial...
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