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Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.

by emottawa | Apr 14, 2014 | Journal Club

Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 2/5   Morelli A, et al. JAMA. 2013 Oct 23;310(16):1683-91 Article Link   This single centre phase 2B trial randomized septic patients still requiring vasopressors after 24hrs of EGDT to...

Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: prospective cohort study.

by emottawa | Apr 7, 2014 | Journal Club

Journal Club Summary Methodology Score: 3/5                  Usefulness Score: 2.5/5   Geersing GJ, et al. BMJ. 2012 Oct 4;345:e6564. Article Link   This was a prospective cohort validation study using the Wells clinical decision rule combined with D-dimer to exclude...

Targeted temperature management at 33°C versus 36°C after cardiac arrest

by emottawa | Mar 31, 2014 | Journal Club

Journal Club Summary Landmark Article Series Nielsen N, et al.; TTM Trial Investigators. N Engl J Med. 2013 Dec 5;369(23):2197-206.   Methodology Score: 5/5                             Usefulness Score: 5/5   Article Link   In this multicenter, international RCT of...

Clopridogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack

by emottawa | Mar 24, 2014 | Journal Club

Journal Club Summary Methodology Score: 4 /5                 Usefulness Score: 3.5/5   Wang Y, Johnston SC, Wang Y. N Engl J Med. 2013 Oct 3;369(14):1376-7. Article Link     This multicenter randomized-control trial of 5,100 patients with TIA/minor stroke treated...

Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature

by emottawa | Mar 17, 2014 | Journal Club

Journal Club Summary Methodology Score: 4.5/5              Usefulness Score: 3/5   Dentali F, Riva N, Crowther M, Turpie AG, Lip GY, Ageno W. Circulation. 2012 Nov 13;126(20):2381-91. Article Link   This was a systematic review and meta-analysis of 12 phase II/III...
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