Question and Methods: Is inhaled budesonide an effective treatment for patients with mild early symptoms of COVID-19? A randomized, open-label clinical trial of community patients with suspected COVID-19.
Findings: Reduction in composite outcome of visits to urgent care, emergency department, or hospitalization in budesonide versus usual care (ARR 0.123; 95% CI 0.033-0.213, p=0.009).
Limitations: Unequal outcomes in composite outcome, open label design, and small sample size due to early trial stoppage.
Interpretation: Based on the limitations, this study – while showing a signal – does not provide enough evidence to warrant routine use of inhaled glucocorticoids for early COVID-19 disease.
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