Methodology: 4/5
Usefulness: 3/5
Crombie N, et al. Lancet Haematol. 2022 Apr;9(4):e250-e261.Â
Question and Methods: Multicenter RCT investigating prehospital resuscitation using PRBC and plasma vs normal saline to improve tissue perfusion or mortality in adult trauma patients with hemorrhagic shock.
Findings: No difference in primary outcome in the PRBCs + plasma vs saline. 65% vs 64% with mortality of 43% v 45% (Adjusted RR 0.97: 0.78-1.20)
Limitations: Trial stopped early. Used a composite outcome which included a surrogate outcome. Limited applicability in most Canadian settings with large distances and long transport times.
Interpretation: No benefit demonstrated to justify the expense and resource utilization for use of PRBCs and lyophilized plasma in pre-hospital EMS treatment of adult trauma patients.
JC Supervisor: Dr. Christian Vaillancourt
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