
Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion
Methodology: 5/5 Usefulness: 4/5 Goyal M, et al. N Engl J Med. 2025 Feb 5. doi: 10.1056/NEJMoa2411668. Question and Methods: This multi-center, open label RCT... Read more.

Failure rate of D-dimer testing in patients with high clinical probability of pulmonary embolism: Ancillary analysis of three European studies
Methodology: 2.5/5 Usefulness: 2/5 Bannelier H, et al. Acad Emerg Med. 2025 Feb;32(2):116-122. doi: 10.1111/acem.15032. Editorial: D-dimer in high-risk pulmonary... Read more.

Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial
Methodology: 4/5 Usefulness: 2/5 Arleth T, et al. JAMA. 2025;333(6):479–489. doi:10.1001/jama.2024.25786 Question and Methods: This multicentered randomized control... Read more.

Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial
Methodology: 3.5/5 Usefulness: 4/5 Taccone FS, et al. JAMA. 2024 Nov 19;332(19):1623-1633. Question and Methods: This multicenter, randomized trial aimed to determine... Read more.

Noninvasive Ventilation for Preoxygenation during Emergency Intubation
Methodology: 4/5 Usefulness: 3.5/5 Gibbs KW, et al. N Engl J Med. 2024 Jun 20;390(23):2165-2177. Question and Methods: The PREOXI trial aimed to determine whether... Read more.

Implementation of Electronic Health Record Integration and Clinical Decision Support to Improve Emergency Department Prescription Drug Monitoring Program Use
Methodology 3/5 Usefulness 2/5 Hoppe JA, et al. Ann Emerg Med. 2024 Jan;83(1):3-13. Question and Methods: The study evaluated whether integrating prescription... Read more.

Andexanet for Factor Xa Inhibitor-Associated Acute Intracerebral Hemorrhage
Methodology 3/5 Usefulness 3/5 Connolly SJ, et al. N Engl J Med. 2024 May 16;390(19):1745-1755. Editorial: Reversing Oral Anticoagulation in Intracerebral Hemorrhage. ... Read more.

PECARN prediction rules for CT imaging of children presenting to the emergency department with blunt abdominal or minor head trauma: a multicentre prospective validation study
Methodology: 3/5 Usefulness: 3/5 Holmes JF, et al. Lancet Child Adolesc Health. 2024 May;8(5):339-347. Question and Methods: This prospective multicenter cohort... Read more.

Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest
Methodology: 4/5 Usefulness: 4/5 Vallentin MF, et al. N Engl J Med. 2024 Oct 31. doi: 10.1056/NEJMoa2407616. Editorial: The Way to a Patient’s Heart –... Read more.

A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest
Methodology: 4/5 Usefulness: 3/5 Couper K, et al. N Engl J Med. 2024 Oct 31:10.1056/NEJMoa2407780. Question and Methods: This multi-center, open label randomized... Read more.