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Hydroxyethyl Starch 130/0.42 versus Ringer’s Acetate in Severe Sepsis

by EMOttawa | Nov 18, 2013 | Journal Club, landmark

Journal Club Summary Landmark Series Methodology Score: 4/5                 Usefulness Score: 4.5/5   Perner A, et al.; 6S Trial Group; Scandinavian Critical Care Trials Group. N Engl J Med. 2012 Jul 12;367(2):124-34   Article Link   This multi-centre, double-blind,...

Meta-analysis of Usefulness of D-dimer to Diagnose Acute Aortic Dissection

by emottawa | Nov 11, 2013 | Journal Club

Journal Club Summary Methodology Score: 3/5                 Usefulness Score: 3/5   Shimony A, Filion KB, Mottillo S, Dourian T, Eisenberg MJ. Am J Cardiol. 2011 Apr 15;107(8):1227-34   Abstract Link   This meta-analysis of seven studies shows a pooled sensitivity...

Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy: a Randomized Clinical Trial

by emottawa | Nov 4, 2013 | Journal Club

Journal Club Summary Methodology Score: 3.5/5               Usefulness Score: 3.5/5   Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA; Emergency Medicine Shock Research Network (EMShockNet) Investigators. JAMA. 2010 Feb 24;303(8):739-46.  Article...

Transfusion Strategies for Acute Upper Gastrointestinal Bleeding

by EMOttawa | Oct 28, 2013 | Journal Club, landmark

Journal Club Summary Landmark Series Methodology Score: 3.5/5               Usefulness Score: 4/5   Villanueva C, Colomo A, Bosch A, Concepción M, Hernandez-Gea V, Aracil C, Graupera I, Poca M, Alvarez-Urturi C, Gordillo J, Guarner-Argente C, Santaló M, Muñiz E,...

Oral Dimenhydrinate versus Placebo in Children with Gastroenteritis: a Randomized Controlled Trial

by emottawa | Oct 21, 2013 | Journal Club

Journal Club Summary Methodology Score: 2.5/5               Usefulness Score: 2/5   Gouin S, Vo TT, Roy M, Lebel D, Gravel J. Pediatrics. 2012 Jun;129(6):1050-5.   Article Link    This randomized, double-blinded, placebo-controlled trial of 144 children in Montreal...

Diuretic Strategies in Patients with Acute Decompensated Heart Failure

by emottawa | Oct 14, 2013 | Journal Club

Journal Club Summary Methodology: 3.5/5 Usefulness: 2/5 Felker GM, et al. NHLBI Heart Failure Clinical Research Network. N Engl J Med. 2011 Mar 3;364(9):797-805 Article Link This double-blind double-dummy RCT (N=308) found that there was no difference in the patient...

Subclinical cerebral edema in children with diabetic ketoacidosis randomized to 2 different rehydration protocols

by emottawa | Sep 9, 2013 | Journal Club

Journal Club Summary Methodology Score: 2/5   Usefulness Score: 2/5   Glaser NS, Wootton-Gorges SL, Buonocore MH, Tancredi DJ, Marcin JP, Caltagirone R, Lee Y, Murphy C, Kuppermann N. Pediatrics. 2013 Jan;131(1):e73-80 Abstract Link   This pilot randomized controlled...

Parenteral dexamethasone for acute severe migraine headache: meta-analysis of randomised controlled trials for preventing recurrence

by EMOttawa | Sep 3, 2013 | Journal Club, landmark

Journal Club Summary Landmark Article Series Methodology Score: 4.5/5  Usefulness Score: 4.5/5 Colman I, Friedman BW, Brown MD, Innes GD, Grafstein E, Roberts TE, Rowe BH. BMJ. 2008 Jun 14;336(7657):1359-61 Article Link    ​In this well performed meta-analysis, a...

Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction

by emottawa | Aug 26, 2013 | Journal Club

Journal Club Summary Methodology Score: 3.5/5  Usefulness Score: 2.5/5   Armstrong PW, et al. STREAM Investigative Team. N Engl J Med. 2013 Apr 11;368(15):1379-87  Abstract Link   This open-label, prospective, randomized, parallel, comparative, international...

Moderate Pulmonary Embolism Treated With Thrombolysis (from the “MOPETT” Trial)

by emottawa | Aug 19, 2013 | Journal Club

Journal Club Summary Methodology Score: 3.5/5               Usefulness Score: 1.5/5   Sharifi M, Bay C, Skrocki L, Rahimi F, Mehdipour M; “MOPETT” Investigators. Am J Cardiol. 2013 Jan 15;111(2):273-7   Article Link   This single-center, open label, randomized control...
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