by Joyes Botros, Jeff Perry, Hans Rosenberg | Apr 18, 2022 | COVID-19, Full Article, Infectious Disease, Journal Club, landmark, Public health
Methodology: 4/5 Usefulness: 4/5 Gupta A, et al. N Engl J Med. 2021 Nov 18;385(21):1941-1950. Question and Methods: COMET-ICE trial evaluated the efficacy and safety of sotrovimab in high-risk, mild-to-moderate Covid-19 not requiring oxygen, within 5 days of symptom...
by Hans Rosenberg | Dec 13, 2021 | Cardiology, Critical Care, Journal Club, landmark, Resuscitation
Methodology: 5/5 Usefulness: 5/5 Dankiewicz J, et al. N Engl J Med. 2021 Jun 17;384(24):2283-2294. Question and Methods: Open-label multicentre randomized controlled trial to determine whether targeted hypothermia reduces mortality compared to targeted normothermia in...
by Hans Rosenberg | Jul 26, 2021 | Full Article, Infectious Disease, Journal Club, landmark, Public health
Methodology: 4/5 Usefulness: 4.5/5 Polack FP, et al. N Engl J Med. 2020 Dec 31;383(27):2603-2615. doi: 10.1056/NEJMoa2034577. Epub 2020 Dec 10. Editorial: SARS-CoV-2 Vaccination – An Ounce (Actually, Much Less) of Prevention. Question/methods: Multinational,...
by Hans Rosenberg | Jul 13, 2020 | Cardiology, Journal Club, landmark
Methodology: 4.5/5 Usefulness: 4/5 Stiell IG, et al. Lancet. 2020 Feb 1;395(10221):339-349 Editorial: Atrial fibrillation cardioversion in the emergency department. Question and Methods: This partial factorial randomized trial aimed to determine which rhythm control...
by Hans Rosenberg | Feb 10, 2020 | Journal Club, landmark, Thrombosis
Methodology Score: 4/5 Usefulness Score: 4.5/5 Kearon C, et al. N Engl J Med. 2019 Nov 28;381(22):2125-2134 Question and Methods: the authors sought to demonstrate safety using a d-dimer cut-off of 1000ng/mL for low pre-test probability patients & a cut-off of...
by Hans Rosenberg | Oct 7, 2019 | cardiac arrest, Cardiology, Journal Club, landmark, Resuscitation
Methodology Score: 4.5/5 Usefulness Score: 3.5/5 Lemkes JS, et al. N Engl J Med. 2019 Apr 11;380(15):1397-1407. Editorial: Coronary Angiography after Cardiac Arrest – The Right Timing or the Right Patients? Question and Methods: Patients with out-of-hospital...
by Hans Rosenberg | Mar 18, 2019 | Critical Care, Full Article, Journal Club, landmark, Neurosurgery
Journal Club Methodology Score: 4/5 Usefulness Score: 3/5 Sprigg N, et al. Lancet. 2018 May 26;391(10135):2107-2115 Question and Methods: Multicenter, double-blinded, randomized, placebo-controlled trial comparing if IV TXA vs placebo, given within 8h of spontaneous...
by Hans Rosenberg | Nov 19, 2018 | Journal Club, landmark, Neurology
Journal Club Summary Methodology Score: 3.5/5 Usefulness Score: 4/5 Johnston SC, et al. N Engl J Med. 2018 Jul 19;379(3):215-225 Editorial: Antiplatelet Therapy after Ischemic Stroke or TIA. Question and Methods: This randomized, double-blind trial evaluated ASA +...
by Hans Rosenberg | Nov 5, 2018 | Anesthesiology, Journal Club, landmark
Journal Club Summary Methodology Score: 4/5 Usefulness Score: 5/5 Nath S, et al. Lancet. 2018 Mar 24;391(10126):1197-1204 Question and Methods: This meta-analysis sought to determine, in lumbar punctures, whether atraumatic or conventional (traumatic) spinal needles...
by Hans Rosenberg | Jun 4, 2018 | Featured, Journal Club, landmark, Neurology
Methodology: 3.5/5 Usefulness: 4/5 Albers GW, et al. N Engl J Med. 2018 Jan 24. Journal Club Bottom Line Question/Methods: This was a multicentre, prospective, randomized, open label, blinded outcome trial comparing thrombectomy + medical therapy vs medical therapy...
