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Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.

by emottawa | Apr 14, 2014 | Journal Club

Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 2/5   Morelli A, et al. JAMA. 2013 Oct 23;310(16):1683-91 Article Link   This single centre phase 2B trial randomized septic patients still requiring vasopressors after 24hrs of EGDT to...

Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: prospective cohort study.

by emottawa | Apr 7, 2014 | Journal Club

Journal Club Summary Methodology Score: 3/5                  Usefulness Score: 2.5/5   Geersing GJ, et al. BMJ. 2012 Oct 4;345:e6564. Article Link   This was a prospective cohort validation study using the Wells clinical decision rule combined with D-dimer to exclude...

Targeted temperature management at 33°C versus 36°C after cardiac arrest

by emottawa | Mar 31, 2014 | Journal Club

Journal Club Summary Landmark Article Series Nielsen N, et al.; TTM Trial Investigators. N Engl J Med. 2013 Dec 5;369(23):2197-206.   Methodology Score: 5/5                             Usefulness Score: 5/5   Article Link   In this multicenter, international RCT of...

Clopridogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack

by emottawa | Mar 24, 2014 | Journal Club

Journal Club Summary Methodology Score: 4 /5                 Usefulness Score: 3.5/5   Wang Y, Johnston SC, Wang Y. N Engl J Med. 2013 Oct 3;369(14):1376-7. Article Link     This multicenter randomized-control trial of 5,100 patients with TIA/minor stroke treated...

Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature

by emottawa | Mar 17, 2014 | Journal Club

Journal Club Summary Methodology Score: 4.5/5              Usefulness Score: 3/5   Dentali F, Riva N, Crowther M, Turpie AG, Lip GY, Ageno W. Circulation. 2012 Nov 13;126(20):2381-91. Article Link   This was a systematic review and meta-analysis of 12 phase II/III...

A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial

by emottawa | Mar 10, 2014 | Journal Club

Journal Club Summary Methodology Score: 2/5                  Usefulness Score: 3.5/5 Zahed R, Moharamzadeh P, Alizadeharasi S, Ghasemi A, Saeedi M.Am J Emerg Med.2013 Sep;31(9):1389-92 Abstract Link This single centre, ED based, parallel group randomized control trial...

The benefits of steroids versus steroids plus antivirals for treatment of Bell’s palsy: a meta-analysis

by emottawa | Mar 3, 2014 | Journal Club

Journal Club Summary Methodology Score: 3.5/5               Usefulness Score: 3.5/5 Quant EC, Jeste SS, Muni RH, Cape AV, Bhussar MK, Peleg AY. BMJ. 2009 Sep 7;339:b3354. doi: 10.1136/bmj.b3354. Article Link This meta-analysis of randomized controlled trials comparing...

A 2-Hour Diagnostic Protocol for Possible Cardiac Chest Pain in the Emergency Department

by emottawa | Jan 27, 2014 | Journal Club

Journal Club Summary Methodology Score: 3.5/5                          Usefulness Score: 3/5   Than M, Aldous S, Lord SJ, Goodacre S, Frampton CM, Troughton R, George P, Florkowski CM, Ardagh M, Smyth D, Jardine DL, Peacock WF, Young J, Hamilton G, Deely JM, Cullen L,...

Clinical Decision Rules to Rule Out Subarachnoid Hemorrhage for Acute Headache

by emottawa | Jan 20, 2014 | Journal Club

Journal Club Summary Methodology Score: 4.5/5                          Usefulness Score: 4/5 Perry JJ, Stiell IG, Sivilotti ML, Bullard MJ, Hohl CM, Sutherland J, Émond M, Worster A, Lee JS, Mackey D, Pauls M, Lesiuk H, Symington C, Wells GA. JAMA....

Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest A Randomized Clinical Trial

by emottawa | Jan 13, 2014 | Journal Club

Journal Club Summary Methodology Score: 4/5                 Usefulness Score: 2.5/5   Mentzelopoulos SD, et al. JAMA. 2013;310(3):270-279. Article Link   This randomized, multi-centered, double blind, placebo controlled trial compared vasopressin, steroids and...
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