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SIRS? No SIRS? Understanding Sepsis in the Emergency Department after Sepsis-3.

SIRS? No SIRS? Understanding Sepsis in the Emergency Department after Sepsis-3.

by emottawa | Mar 2, 2017 | Grand Round Summaries, Resuscitation

Use of the term “sepsis” continues to be controversial. We understand that patients with infection can manifest an immune-mediated systemic response, and are at risk of deterioration, organ dysfunction, and death. At what point in that cascade the patient is termed...

Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis: The HYPRESS Randomized Clinical Trial

by emottawa | Feb 27, 2017 | Journal Club

Journal Club Summary   Methodology Score: 3/5                    Usefulness Score:  2.5/5   Keh D, et al. JAMA. 2016 Nov 1;316(17):1775-1785 Abstract Link In this multicenter placebo-controlled double-blind RCT, the authors concluded that in adults with severe sepsis,...

Assessment of Clinical Criteria for Sepsis For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

by emottawa | May 24, 2016 | Journal Club

Journal Club Summary Methodology Score: 3.5/5               Usefulness Score: 3 /5   Seymour CW, et al.  JAMA. 2016 Feb 23;315(8):762-74 Abstract Link   Editorial: New Definitions for Sepsis and Septic Shock Continuing Evolution but With Much Still to Be Done Abraham...
To ‘Roid or not to ‘Roid: Steroids in the ED!

To ‘Roid or not to ‘Roid: Steroids in the ED!

by emottawa | Mar 1, 2016 | Endocrinology, Grand Round Summaries

      Steroids have been used in medicine for their immune-modulating effects for decades, but how much of their use is actually evidence based?  Here we review the most recent literature for their use in four select presentations often seen in the Emergency...

Systemic inflammatory response syndrome criteria in defining severe sepsis

by emottawa | Nov 3, 2015 | Journal Club

Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 3.5/5   Kaukonen KM, Bailey M, Pilcher D, et al. N Engl J Med. 2015 Apr 23;372(17):1629-38. Full Article   This retrospective multicenter study found that the use of SIRS criteria to define...
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