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Assessment of Clinical Criteria for Sepsis For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

by emottawa | May 24, 2016 | Journal Club

Journal Club Summary Methodology Score: 3.5/5               Usefulness Score: 3 /5   Seymour CW, et al.  JAMA. 2016 Feb 23;315(8):762-74 Abstract Link   Editorial: New Definitions for Sepsis and Septic Shock Continuing Evolution but With Much Still to Be Done Abraham...
To ‘Roid or not to ‘Roid: Steroids in the ED!

To ‘Roid or not to ‘Roid: Steroids in the ED!

by emottawa | Mar 1, 2016 | Endocrinology, Grand Round Summaries

      Steroids have been used in medicine for their immune-modulating effects for decades, but how much of their use is actually evidence based?  Here we review the most recent literature for their use in four select presentations often seen in the Emergency...

Systemic inflammatory response syndrome criteria in defining severe sepsis

by emottawa | Nov 3, 2015 | Journal Club

Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 3.5/5   Kaukonen KM, Bailey M, Pilcher D, et al. N Engl J Med. 2015 Apr 23;372(17):1629-38. Full Article   This retrospective multicenter study found that the use of SIRS criteria to define...

A randomized trial of protocol-based care for early septic shock

by emottawa | Oct 27, 2014 | Journal Club

Journal Club Summary Landmark Series Methodology Score: 4/5 Usefulness Score:  4/5 ProCESS Investigators  N Engl J Med. 2014 May 1;370(18):1683-93. Abstract Link    This large multicentre U.S. RCT of 1341 septic patients found no significant differences in mortality...

Albumin replacement in patients with severe sepsis or septic shock

by emottawa | Sep 22, 2014 | Journal Club

Journal Club Summary Methodology Score: 3.5/5              Usefulness Score: 2.5/5   Caironi P, Tognoni G, et al. the ALBIOS Study Investigators. N Engl J Med. 2014 Mar 18. Abstract Link   This was an open-label RCT of 1,800 ICU patients with severe sepsis or septic...
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