septic shock Archives

Adjunctive Glucocorticoid Therapy in Patients with Septic Shock

by Hans Rosenberg | Jun 11, 2018 | Critical Care, Endocrinology, Journal Club, Resuscitation

Methodology Score: 4/5 Usefulness Score: 3/5 Venkatesh B, et al. N Engl J Med. 2018 Jan 19. Journal Club Bottom Line Question/Methods: This was a international, pragmatic, double-blind, randomized, controlled trial comparing hydrocortisone as continuous infusion to...

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis

by Hans Rosenberg | Sep 11, 2017 | Critical Care, Infectious Disease, Journal Club

Journal Club Summary Seymour CW, et al. Journal N Engl J Med. 2017 Jun 8;376(23):2235-2244. EDITORIAL: State Sepsis Mandates – A New Era for Regulation of Hospital Quality. Hershey TB, et al. N Engl J Med. 2017 May 21. Methodology Score: 3.5/5 Usefulness Score:...

Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis: The HYPRESS Randomized Clinical Trial

by emottawa | Feb 27, 2017 | Journal Club

Journal Club Summary Methodology Score: 3/5 Usefulness Score: 2.5/5 Keh D, et al. JAMA. 2016 Nov 1;316(17):1775-1785 Abstract Link In this multicenter placebo-controlled double-blind RCT, the authors concluded that in adults with severe sepsis,...

Goal-directed resuscitation for patients with early septic shock.

by emottawa | Apr 1, 2015 | Journal Club

Journal Club Summary Landmark Series Methodology Score: 4/5 Usefulness Score: 5/5 ARISE Investigators and the ANZICS Clinical Trials Group. N Engl J Med. 2014 Oct 16;371(16):1496-506 Abstract Link ARISE was a multicenter, international ED...

High versus Low Blood-Pressure Target in Patients with Septic Shock

by emottawa | Feb 9, 2015 | Journal Club

Journal Club Summary Methodology Score: 4.5 Usefulness Score: 4.5 Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, et al. for the SEPSISPAM Investigators. N Engl J Med. 2014 Apr 24;370(17):1583-93 Full Article This multi-centre,...