A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest

by , , | Jan 6, 2025 | 0 comments

Ambulance on the street

Methodology: 4/5
Usefulness: 3/5

Couper K, et al. N Engl J Med. 2024 Oct 31:10.1056/NEJMoa2407780.

Question and Methods: This multi-center, open label randomized control trial aimed to assess 30-day survival in patients with out of hospital cardiac arrest (OOHCA) who received IO versus IV access first. 
Findings: There was no statistically significant difference in 30-day survival in patients who received IO versus IV vascular access (4.5% IO vs. 5.1% IV; adjusted odds ratio 0.94; 95% confidence interval (CI), 0.68-1.32; p=0.74).
Limitations: Limitations of this study include a lack of blinding and the study being stopped early. 

Interpretation: There was no significant difference in 30-day survival for OOHCA when comparing IO versus IV access, suggesting that both options would be reasonable for vascular access.

Dr. Hailey Newton

JC Supervisor: Dr. Vaillancourt

 

 

Authors

  • Dr. Newton is an FRCPC Emergency Medicine resident at the University of Ottawa.

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  • Dr. Hans Rosenberg

    Dr. Rosenberg is an emergency physician at the Ottawa Hospital, associate professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.

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  • Christian Vaillancourt

    Senior Scientist, Clinical Epidemiology Program Ottawa Hospital Research Institute Full Professor, Emergency Medicine University of Ottawa Research Chair in Emergency Cardiac Resuscitation, Emergency Medicine University of Ottawa Associate Medical Director, Regional Paramedic Program for Eastern Ontario Research Interests: Dr. Vaillancourt's current research program focuses on pre-hospital care, specifically improving care and survival for cardiac arrest and trauma victims.

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