Methodology: 4/5
Usefulness: 2/5
Arleth T, et al. JAMA. 2025;333(6):479–489. doi:10.1001/jama.2024.25786
Question and Methods: This multicentered randomized control trial allocated trauma patients to a liberal or restrictive oxygen strategy for 8 hours to examine outcomes of death and/or respiratory complications.
Findings: The study found there was no difference between the groups with outcome of death and/or respiratory complications between the restrictive (16.1%) and liberal oxygen groups (16.7%).
Limitations: The study is limited by its open-label design, retrospective exclusion of study population, use of composite outcomes, and only 8 hours of intervention for study patients
Interpretation: This paper shows that there is no reason to restrict oxygen in initial management of trauma patients. However, local practice is more consistent with the study’s restrictive group which is safe to continue.
JC Supervisor: Dr. Krishan Yadav
