
Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion
Methodology: 5/5 Usefulness: 4/5 Goyal M, et al. N Engl J Med. 2025 Feb 5. doi: 10.1056/NEJMoa2411668. Question and Methods: This multi-center, open label RCT... Read more.

Failure rate of D-dimer testing in patients with high clinical probability of pulmonary embolism: Ancillary analysis of three European studies
Methodology: 2.5/5 Usefulness: 2/5 Bannelier H, et al. Acad Emerg Med. 2025 Feb;32(2):116-122. doi: 10.1111/acem.15032. Editorial: D-dimer in high-risk pulmonary... Read more.

Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial
Methodology: 4/5 Usefulness: 2/5 Arleth T, et al. JAMA. 2025;333(6):479–489. doi:10.1001/jama.2024.25786 Question and Methods: This multicentered randomized control... Read more.

Implementation of Electronic Health Record Integration and Clinical Decision Support to Improve Emergency Department Prescription Drug Monitoring Program Use
Methodology 3/5 Usefulness 2/5 Hoppe JA, et al. Ann Emerg Med. 2024 Jan;83(1):3-13. Question and Methods: The study evaluated whether integrating prescription... Read more.

Andexanet for Factor Xa Inhibitor-Associated Acute Intracerebral Hemorrhage
Methodology 3/5 Usefulness 3/5 Connolly SJ, et al. N Engl J Med. 2024 May 16;390(19):1745-1755. Editorial: Reversing Oral Anticoagulation in Intracerebral Hemorrhage. ... Read more.

Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial
Methodology: 3.5/5 Usefulness: 3/5 Freund Y, et al. JAMA. 2023 Dec 19;330(23):2267-2274. Question and Methods: Multicenter RCT involving comatose patients with... Read more.

Risk Scores for Clinical Risk Stratification of Emergency Department Patients With Chest Pain but No Acute Myocardial Infarction: A Systematic Review
Methodology: 3/5 Usefulness: 3/5 O’Rielly CM, et al. Can J Cardiol. 2023 Mar;39(3):304-310. doi: 10.1016/j.cjca.2022.12.028. Question and Methods: The authors... Read more.

Multifaceted quality improvement initiatives improve rate of pediatric hand injury reduction
Methodology: 2/5 Usefulness: 3/5 Market M, et al. CJEM. 2022 Jun;24(4):426-433. Question & methods: Whether quality improvement interventions could decrease... Read more.

Hydrocortisone in Severe Community-Acquired Pneumonia
Methodology: 4/5 Usefulness: 4/5 Dequin PF, et al. N Engl J Med. 2023 Mar 21. doi: 10.1056/NEJMoa2215145. Question and Methods: Pneumosepsis can lead to pulmonary... Read more.

Defibrillation Strategies for Refractory Ventricular Fibrillation
Methodology: 4.5/5 Usefulness: 4.5/5 Cheskes S, et al. N Engl J Med. 2022 Nov 6. Question and Methods: A cluster-randomized open-label trial evaluating survival... Read more.