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A non-inferiority randomized controlled trial of a shorter acetylcysteine regimen for paracetamol overdose – the SARPO trial

by Maria Berliant, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | Dec 1, 2025 | Full Article, Gastroenterology, Journal Club, Toxicology

Methodology: 3.5/5 Usefulness: 4/5 Isbister G, et al. J Hepatol. 2025 Oct;83(4):881-887. doi: 10.1016/j.jhep.2025.05.008. Question and Methods: This multicentre unblinded RCT with 204 patients assessed non-inferiority of a 12-hour NAC protocol for single non-massive...

Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial

by emottawa | Jul 28, 2014 | Journal Club

Journal Club Summary Methodology Score: 4/5 Usefulness Score: 2/5 Bateman DN, et al. Lancet. 2014 Feb 22;383(9918):697-704 Article Link This 2×2 factorial, intention to treat, randomized controlled trial of paracetamol overdose showed a...

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A non-inferiority randomized controlled trial of a shorter acetylcysteine regimen for paracetamol overdose – the SARPO trial

Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial

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