Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial
Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial. Hernandez G, ANDROMEDA-SHOCK-2... Read more.
A Randomized Trial of Shared Decision-Making in Code Status Discussions.
A Randomized Trial of Shared Decision-Making in Code Status Discussions Becker C, et al. NEJM Evid. 2025 May;4(5):EVIDoa2400422. doi: 10.1056/EVIDoa2400422. ... Read more.
Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5): a multicentre, prospective, randomised, open-label, blinded-endpoint, superiority, phase 3 trial.
Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5): a multicentre, prospective, randomised, open-label, blinded-endpoint,... Read more.
Intravenous Tenecteplase before Thrombectomy in Stroke
Methodology: 4/5 Usefulness: 4/5 Qiu Z, et al. N Engl J Med. 2025 Jul 10;393(2):139-150. doi: 10.1056/NEJMoa2503867. Question and Methods: This multi-center, open-label... Read more.
Magnesium Sulfate Versus Lidocaine as an Adjunct for Renal Colic in the Emergency Department: A Randomized, Double-Blind Controlled Trial
Methodology: 4/5 Usefulness: 3.5/5 Toumia M, et al. Ann Emerg Med. 2024 Dec;84(6):670-677. doi: 10.1016/j.annemergmed.2024.06.015. Question and Methods: This double-blinded... Read more.
A non-inferiority randomized controlled trial of a shorter acetylcysteine regimen for paracetamol overdose – the SARPO trial
Methodology: 3.5/5 Usefulness: 4/5 Isbister G, et al. J Hepatol. 2025 Oct;83(4):881-887. doi: 10.1016/j.jhep.2025.05.008. Question and Methods: This multicentre... Read more.
Test Characteristics of Emergency Medicine-Performed Point-of-Care Ultrasound for the Diagnosis of Acute Cholecystitis: A Systematic Review and Meta-analysis
Methodology: 4/5 Usefulness: 3.5/5 Wilson SJ, et al. Ann Emerg Med. 2024 Mar;83(3):235-246. doi: 10.1016/j.annemergmed.2023.09.005. Questions and Method: To determine... Read more.
Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage
Methodology: 4/5 Usefulness: 3/5 English SW, et al. N Engl J Med. 2025 Mar 13;392(11):1079-1088. doi: 10.1056/NEJMoa2410962. Question and Methods: This multicenter... Read more.
Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial
Methodology: 3/5 Usefulness: 3/5 Luo Z, et al. JAMA. 2024;332(20):1709–1722. doi:10.1001/jama.2024.15815 Question and Methods: Multi-centre, randomized control... Read more.
Out-of-Hospital Intranasal Ketamine as an Adjunct to Fentanyl for the Treatment of Acute Traumatic Pain: A Randomized Clinical Trial
Methodology: 4/5 Usefulness: 2/5 McMullan JT, et al. Ann Emerg Med. 2024 Oct;84(4):363-373. doi: 10.1016/j.annemergmed.2024.04.018. Question and Methods: This... Read more.