A randomized double-blind trial comparing the effect on pain of an oral sucrose solution versus placebo in children 1-3 months old needing bladder catheterization

A randomized double-blind trial comparing the effect on pain of an oral sucrose solution versus placebo in children 1-3 months old needing bladder catheterization

Methodology: 4/5 Usefulness: 2/5 Desjardins MP, et al. CJEM. 2021 Sep;23(5):655-662. doi: 10.1007/s43678-021-00130-x. Epub 2021 May 26. Question and Methods: This double-blinded RCT compares analgesic efficacy of oral sucrose versus placebo in bladder catheterization...
Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7-Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients with Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial

Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7-Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients with Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial

Methodology: 1/5           Usefulness: 1/5 von Dach E, et al. JAMA. 2020 Jun 2;323(21):2160-2169. doi: 10.1001/jama.2020.6348. Question and Methods: In a multi-center, noninferiority, randomized, double-blinded clinical trial, the authors compared the rates of...
Short-Term Topical Tetracaine Is Highly Efficacious for the Treatment of Pain Caused by Corneal Abrasions: A Double-Blind, Randomized Clinical Trial

Short-Term Topical Tetracaine Is Highly Efficacious for the Treatment of Pain Caused by Corneal Abrasions: A Double-Blind, Randomized Clinical Trial

Methodology: 2/5           Usefulness: 2/5  Shipman S, et al. Ann Emerg Med. 2021 Mar;77(3):338-344. doi: 10.1016/j.annemergmed.2020.08.036.  Question and Methods: Double blinded RCT comparing tetracaine versus placebo eye drops for 24 hours in the treatment of pain...
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis

Methodology: 4/5 Usefulness: 4/5 WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne JAC et al. JAMA. 2020 Oct 6;324(13):1330-1341. Question and Methods: Prospective meta-analysis of 7 RCTs investigating the utility of systemic...
Plaster cast versus functional brace for non-surgical treatment of Achilles tendon rupture (UKSTAR): a multicentre randomised controlled trial and economic evaluation

Plaster cast versus functional brace for non-surgical treatment of Achilles tendon rupture (UKSTAR): a multicentre randomised controlled trial and economic evaluation

Methodology: 3.5/5 Usefulness: 3.5/5 Costa ML et al. Lancet. 2020 Feb 8;395(10222):441-448. Question and Methods: The UKSTAR trial was a pragmatic, multicenter RCT that compared plaster cast against walking boot for non-operative management of Achilles tendon rupture...