Question and Methods: Retrospective cohort study evaluating risk of ICH post head injury in ED patients >65 years on warfarin or DOAC or no anticoagulant.
Findings: Patients on warfarin had an increased risk of ICH compared with matched patients on DOACs (RR 1.43, 95% CI 1.20–1.69) and no anticoagulation (RR 1.36, 95% CI 1.15–1.61). No difference in ICH between patients not on anticoagulation and DOACS.
Limitations: No laboratory data to evaluate coagulation markers
Interpretation: Patients on warfarin with head injury had higher relative risk of ICH than matched patients on DOAC and no anticoagulation.
Supervision: Dr. Jeff Perry