Methodology: 4/5
Usefulness: 3/5

Meyhoff TS, et al. N Engl J Med. 2022 Jun 30;386(26):2459-2470.

Question and Methods: International, stratified, parallel group, open-label, randomized clinical trial where ICU patients were randomized to restrictive or standard fluid therapy. 
Findings: There was no difference in the primary outcome of death at 90 days between restrictive and standard fluid therapy.
Limitations: Major limitation is that the study was unblinded, and there was significant overlap of IQRs of fluid received in the assigned groups. 

Interpretation: Restrictive fluid administration did not impact 90-day mortality in ICU patients, and does not impact initial ED management. 

By: Dr. Zachary MacDonald

JC Supervisor: Dr. Christian Vaillancourt