Methodology: 4/5
Usefulness: 3/5

Meyhoff TS, et al. N Engl J Med. 2022 Jun 30;386(26):2459-2470.

Question and Methods: International, stratified, parallel group, open-label, randomized clinical trial where ICU patients were randomized to restrictive or standard fluid therapy. 
Findings: There was no difference in the primary outcome of death at 90 days between restrictive and standard fluid therapy.
Limitations: Major limitation is that the study was unblinded, and there was significant overlap of IQRs of fluid received in the assigned groups. 

Interpretation: Restrictive fluid administration did not impact 90-day mortality in ICU patients, and does not impact initial ED management. 

By: Dr. Zachary MacDonald

JC Supervisor: Dr. Christian Vaillancourt




  • Zach MacDonald

    Dr. Zach MacDonald is an Emergency Physician in the Department of Emergency Medicine, at the University of Ottawa, having completed his FRCPC residency in Ottawa.

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  • Hans Rosenberg

    Dr. Rosenberg is an emergency physician at the Ottawa Hospital, associate professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.

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  • Christian Vaillancourt

    Senior Scientist, Clinical Epidemiology Program Ottawa Hospital Research Institute Full Professor, Emergency Medicine University of Ottawa Research Chair in Emergency Cardiac Resuscitation, Emergency Medicine University of Ottawa Associate Medical Director, Regional Paramedic Program for Eastern Ontario Research Interests: Dr. Vaillancourt's current research program focuses on pre-hospital care, specifically improving care and survival for cardiac arrest and trauma victims.

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