Methodology: 3/5
Usefulness: 1/5

Georgiopoulos G, et al. JAMA Cardiol. 2023 Oct 1;8(10):946-956

Question: Does the modified GRACE score incorporating continuous troponin improve ACS risk prediction?

Methods: Retrospective longitudinal cohort study examining 3 independent cohorts (2 derivation and 1 validation).
Findings: The modified GRACE score incorporating continuous troponin (rather than binary) showed improved performance compared with the original GRACE score and other well-established prognostic markers.
Limitations: The recruitment periods of both the derivation and validation cohorts have significant overlap, thus predisposing the data to bias.

Interpretation: Modified GRACE score improved prediction of short-term and long-term mortality across the spectrum of ACS. Prior to widespread adoption, prospective cohort studies should be performed.

By: Dr. Kevin Durr

JC Supervisor: Dr. Jeff Perry




  • Kevin Durr

    Dr. Kevin Durr is an FRCPC Emergency Medicine resident the University of Ottawa

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  • Hans Rosenberg

    Dr. Rosenberg is an emergency physician at the Ottawa Hospital, associate professor at the University of Ottawa, and Director of the Digital Scholarship and Knowledge Dissemination Program.

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  • Jeff Perry

    Dr. Perry is an Emergency Physician and full Professor in the department of Epidemiology and Community Medicine. He has a special research interest in subarachnoid hemorrhage, TIA and stroke.

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