Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial

Methodology: 4/5 Usefulness: 3/5 Fujii T, et al. JAMA. 2020 Jan 17. doi: 10.1001/jama.2019.22176. [Epub ahead of print] Editorial: Lack of Benefit of High-Dose Vitamin C, Thiamine, and Hydrocortisone Combination for Patients With Sepsis. Question and Methods:...

Hydrocortisone therapy for patients with septic shock

Journal Club Summary Landmark Series  Methodology Score: 3.5/5               Usefulness Score: 3.5/5   Sprung CL, et al. CORTICUS Study Group. N Engl J Med. 2008 Jan 10;358(2):111-24 Article Link   This Multicenter, double-blind, parallel-group, placebo-controlled RCT...