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Blood Pressure Targets in Trauma Resuscitation: The New Thinking

Blood Pressure Targets in Trauma Resuscitation: The New Thinking

by Mathieu McKinnon | Mar 26, 2026 | Anesthesiology, Critical Care, Featured, Grand Round Summaries, Resuscitation, Trauma

Blood pressure management in trauma is one of the most deceptively complex decisions we make in the emergency department. In the first hour of resuscitation, competing physiologic priorities collide: permissive hypotension may protect clot integrity in hemorrhagic...
Signal or Noise? Using Inflammatory Markers Wisely Through a Bayesian Lens

Signal or Noise? Using Inflammatory Markers Wisely Through a Bayesian Lens

by Lucy Karp | Mar 19, 2026 | Featured, Gastroenterology, Grand Round Summaries, Immunology, Infectious Disease, Most Viewed, Ophthalmology, Rheumatology

There seems to be a growing cultural obsession with “inflammation”. Scroll through social media long enough and you’ll find sweeping claims: inflammation is the root of fatigue, weight gain, menstrual cramps, brain fog, and even depression. And alongside this...
Smarter Starts and Safer Stops: Antibiotic Stewardship in the ED

Smarter Starts and Safer Stops: Antibiotic Stewardship in the ED

by Mejbel Alazemi | Mar 12, 2026 | Critical Care, Featured, Grand Round Summaries, Infectious Disease, Resuscitation

Antimicrobial stewardship (AMS) is about using the right antibiotic, only when needed, and choosing the appropriate dose, route, and duration. The goal is to treat infections effectively while reducing harm, both to the individual and to the healthcare system. It’s...
Vernakalant versus procainamide for rapid cardioversion of patients with acute atrial fibrillation (RAFF4): randomised clinical trial

Vernakalant versus procainamide for rapid cardioversion of patients with acute atrial fibrillation (RAFF4): randomised clinical trial

by Anchaleena Mandal, Christian Vaillancourt | Mar 5, 2026 | Featured

Methodology Score: 4.5/5 Usefulness Score: 4/5 Stiell IG, et al. BMJ. 2025 Nov 11;391:e085632. doi: 10.1136/bmj-2025-085632. Question and Methods: This is a multi-center, open-label, patient randomised trial comparing the effectiveness and safety of cardioversion with...
Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults

Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults

by Mathieu McKinnon, Jeff Perry, Shahbaz Syed | Mar 3, 2026 | Featured, Journal Club

Methodology: 4/5 Usefulness: 4/5 N Engl J Med. 2025 Dec 9. doi: 10.1056/NEJMoa2511420. Question and Methods: This multi-center, open label RCT of 2359 patients compared 28-day mortality in patients randomized to receiving ketamine or etomidate for their sedation prior...
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