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Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial

Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial

by Alie Wudwud, Hans Rosenberg, Christian Vaillancourt | Mar 24, 2025 | Featured, Journal Club, Neurosurgery, Trauma

Methodology: 3.5/5 Usefulness: 4/5 Taccone FS, et al. JAMA. 2024 Nov 19;332(19):1623-1633. Question and Methods: This multicenter, randomized trial aimed to determine the optimal hemoglobin transfusion threshold in patients with acute brain injury, comparing a...
Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia

Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia

by Suzanne Boroumand, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | May 31, 2024 | Cardiology, Hematology, Journal Club

Methodology: 4/5 Usefulness: 3.5/5 Carson JL, et al. N Engl J Med. 2023 Dec 28;389(26):2446-2456. doi: 10.1056/NEJMoa2307983.  Questions and methods: This multicenter, open-label, RCT of 3604 patients with MI with anemia compared 30-day all-cause mortality and...
Updates in Prehospital and Transport Medicine

Updates in Prehospital and Transport Medicine

by Daniel Beamish, Richard Hoang, Shankar Sethuraman | Jul 25, 2019 | Grand Round Summaries, Pre-Hospital, Resuscitation, Trauma

There was a significant amount of pre-hospital research published in 2018; many trials were that will no doubt inform future guidelines and change practice. This post seeks to look at some of the historical features of prehospital research and give us a road map for...

Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomized feasibility trial

by emottawa | Jan 30, 2017 | Journal Club

Journal Club Summary Methodology Score: 3/5                    Usefulness Score: 2/5   Jairath V, et al. Lancet. 2015 Jul 11;386(9989):137-44 Abstract Link This open label, cluster randomized feasibility trial based in six university hospitals in the United Kingdom...
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World-Class Emergency Medicine: To provide outstanding compassionate emergency care through practice-changing research and innovative medical education. For more about our department, visit us at EMOttawa.

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World-Class Emergency Medicine: To provide outstanding compassionate emergency care through practice-changing research and innovative medical education. For more about our department, visit us at EMOttawa.

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