by Renee Bradley, Hans Rosenberg, Jeff Perry | May 2, 2022 | Critical Care, Journal Club, Neurology, Neurosurgery
Methodology: 4.5/5 Usefulness: 4/5 Post R, et al. Lancet. 2021 Jan 9;397(10269):112-118. doi: 10.1016/S0140-6736(20)32518-6. Question and Methods: This prospective, multicentre, randomized, controlled, open-label trial investigated whether administering TXA...
by Graham Wilson, Jeff Perry, Hans Rosenberg | Apr 4, 2022 | Full Article, Journal Club, Neurosurgery, Thrombosis, Trauma
Methodology: 3/5 Usefulness: 3/5 Grewal K, et al. CMAJ. 2021 Oct 12;193(40):E1561-E1567. Question and Methods: Retrospective cohort study evaluating risk of ICH post head injury in ED patients >65 years on warfarin or DOAC or no anticoagulant. Findings: Patients...
by Maeghan Fu, Josee Malette, Pascale King | Mar 11, 2021 | Grand Round Summaries, Hematology, Neurosurgery, Resuscitation, Trauma
Tick. Tock. It’s time for a TXA update. This blog post aims to arm you with the most up-to-date knowledge for the use of tranexamic acid (TXA) in the ED. We will review TXA in the context of gastrointestinal bleeding, traumatic brain injuries, hemoptysis,...
by Hans Rosenberg | Jan 11, 2021 | Journal Club, Neurosurgery, Trauma
Methodology: 2/5 Usefulness: 4/5 Leichtle SW, et al. J Trauma Acute Care Surg. 2020 Nov;89(5):880-886. Question and Methods: Existing BCVI screening guidelines misses important injuries; the authors evaluated the diagnostic characteristics of the Modified and...
by Hans Rosenberg | Jan 3, 2021 | Full Article, Journal Club, Neurosurgery
Methodology: 4/5 Usefulness: 4/5 Perry JJ, et al. Stroke. 2020 Feb;51(2):424-430. doi: 10.1161/STROKEAHA.119.026969. Question and Methods: Prospective, multi-center before and after study looking at the implementation of the Ottawa Subarachnoid Hemorrhage Rule and...
by Michael Hale, Kate O'Connell | Nov 5, 2020 | Featured, Grand Round Summaries, Neurosurgery, Radiology
The diagnosis of subarachnoid hemorrhage (SAH) carries with it remarkable morbidity and mortality. Case fatality rates approach 50% 1,2 Of those who survive, half will experience chronic disability and a significant reduction in health-related quality of...
by Hans Rosenberg | Dec 16, 2019 | Full Article, Journal Club, Neurosurgery, Resuscitation, Trauma
Methodology Score: 3/5 Usefulness Score: 3/5 Cooper DJ, et al. JAMA. 2018;320(21):2211-2220. doi:10.1001/jama.2018.17075 Question/Methods: This study was done to determine the effectiveness of early prophylactic hypothermia compared with normothermic management of...
by Hans Rosenberg | Dec 9, 2019 | Full Article, Neurosurgery, Trauma
Methodology: 3.5/5 Usefulness: 3.5/5 The CRASH-3 trial collaborators. The Lancet. 2019 Oct 14. Online First Editorial: CRASH-3: a win for patients with traumatic brain injury Question and Methods: Multi-centre, randomized, placebo-controlled trial looking at whether...
by Hans Rosenberg | Jul 10, 2019 | Full Article, Journal Club, Neurosurgery, Orthopedics
Journal Club Summary Methodology: 3.5/5 Usefulness: 4/5 Mathieson S, et al. N Engl J Med. 2017 Mar 23;376(12):1111-1120. Question and Methods: Double blind, randomized control trial comparing pregabalin against placebo for reducing leg pain symptoms at 8 weeks in 209...
by Hans Rosenberg | Mar 18, 2019 | Critical Care, Full Article, Journal Club, landmark, Neurosurgery
Journal Club Methodology Score: 4/5 Usefulness Score: 3/5 Sprigg N, et al. Lancet. 2018 May 26;391(10135):2107-2115 Question and Methods: Multicenter, double-blinded, randomized, placebo-controlled trial comparing if IV TXA vs placebo, given within 8h of spontaneous...
