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In: Full Article, Journal Club, Neurosurgery, Resuscitation, Trauma

Methodology Score: 3/5 Usefulness Score: 3/5 Cooper DJ, et al. JAMA. 2018;320(21):2211-2220. doi:10.1001/jama.2018.17075 Question/Methods: This study was done to determine the effectiveness of early prophylactic hypothermia compared with normothermic management of patients after severe traumatic brain injury (TBI). Findings:  No statistically significant difference in favorable neurologic outcomes at 6 months wasRead More →

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In: Full Article, Neurosurgery, Trauma

Methodology: 3.5/5 Usefulness: 3.5/5 The CRASH-3 trial collaborators. The Lancet. 2019 Oct 14. Online First Editorial: CRASH-3: a win for patients with traumatic brain injury Question and Methods: Multi-centre, randomized, placebo-controlled trial looking at whether TXA (1g over 10 minutes followed by infusion over 8 hours) reduces mortality in patientsRead More →

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In: Full Article, Journal Club, Neurosurgery, Orthopedics

Journal Club Summary Methodology: 3.5/5 Usefulness: 4/5 Mathieson S, et al. N Engl J Med. 2017 Mar 23;376(12):1111-1120.  Question and Methods: Double blind, randomized control trial comparing pregabalin against placebo for reducing leg pain symptoms at 8 weeks in 209 patients with acute and chronic sciatica. Findings: The authors found a betweenRead More →

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In: Critical Care, Full Article, Journal Club, Neurology, Neurosurgery

Journal Club Methodology Score: 4/5 Usefulness Score: 3/5 Sprigg N, et al. Lancet. 2018 May 26;391(10135):2107-2115 Question and Methods: Multicenter, double-blinded, randomized, placebo-controlled trial comparing if IV TXA vs placebo, given within 8h of spontaneous (non-traumatic) ICH onset, decreased death or dependence at 90 days. Findings: No difference in 90dRead More →