Early versus delayed antihypertensive treatment in patients with acute ischaemic stroke: multicentre, open label, randomised, controlled trial

Early versus delayed antihypertensive treatment in patients with acute ischaemic stroke: multicentre, open label, randomised, controlled trial

by , , | Jan 2, 2024 | Critical Care, Full Article, Journal Club, Neurology

Methodology: 4/5 Usefulness: 2/5 Liu L, et al. BMJ. 2023 Oct 9;383:e076448.  Question: Do early vs delayed blood pressure management in patients with mild-moderate acute ischemic strokes decrease death or dependency at 90 days? Methods: Randomization to early (24 hrs)...
Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial

Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial

by , , | Nov 27, 2023 | Journal Club, Trauma

Methodology: 2/5 Usefulness: 2/5 Jansen JO, et al. JAMA. 2023 Oct 12:e2320850.  Editorial: Contemporary Adjuncts to Hemorrhage Control. Question and Methods: Multi-center pragmatic Bayesian RCT comparing 90d all-cause mortality and 10 secondary outcomes in trauma...
Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury: The CRYOSTAT-2 Randomized Clinical Trial

Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury: The CRYOSTAT-2 Randomized Clinical Trial

by , , | Nov 22, 2023 | Featured, Full Article, Hematology, Journal Club, Trauma

Methodology: 3.5/5 Usefulness: 4/5 Davenport R, et al. JAMA. 2023 Oct 12:e2321019.  Editorial: Contemporary Adjuncts to Hemorrhage Control. Question and Methods: In trauma patients with major hemorrhage, does early cryoprecipitate (6g fibrinogen) administration...
The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

by , , | Nov 6, 2023 | Critical Care, Full Article, Journal Club, Neurology

Methodology: 4/5 Usefulness: 4/5 Ma L, et al. Lancet 2023 Jul 1;402(10395):27-40. Question and Methods: Do 6 month outcomes improve after implementation of a goal-directed care bundle that corrects prognostically poor physiological abnormalities (systolic...