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Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

by Hans Rosenberg | Mar 22, 2021 | Journal Club, Neurology

Methodology: 4/5 Usefulness: 3.5/5 Thomalla G, et al. Lancet. 2020 Nov 14;396(10262):1574-1584 Question and Methods: The authors evaluated the role of perfusion-imaging facilitated thrombolysis in strokes of unknown duration by way of a systematic review and...
Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA.

Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA.

by Hans Rosenberg | Nov 9, 2020 | Journal Club, Neurology

Methodology: 2/5 Usefulness: 2/5 Johnston SC, et al. N Engl J Med. 2020 Jul 16;383(3):207-217. Question and Methods: Multicentre, double-blind RCT of ASA vs Ticagrelor-ASA among 11016 patients with high-risk TIA or minor stroke for prevention of stroke/death within 30...
Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

by Hans Rosenberg | Jul 29, 2019 | Journal Club, Neurology

Journal Club Summary Methodology: 3.5/5 Usefulness: 2.5/5 Ma H, et al N Engl J Med. 2019 May 9;380(19):1795-1803 Editorial: Image-Guided Intravenous Alteplase for Stroke – Shattering a Time Window.  Question and Methods: This was an international, multicenter,...
An Update on the ED Management of Acute Ischemic Stroke and TIA

An Update on the ED Management of Acute Ischemic Stroke and TIA

by Michael Hale, Richard Hoang, Shankar Sethuraman | Jun 13, 2019 | Grand Round Summaries, Neurology

Ischemic stroke is one of Canada’s leading causes of morbidity and mortality. Over the last 30 years, we have observed rapid advances concerning how we identify, respond to, and treat patients with acute ischemic stroke. Because this topic is so vast, the focus of...
Identifying stroke mimics in the ED

Identifying stroke mimics in the ED

by Katherine Soucie, Richard Hoang, Shankar Sethuraman | Feb 14, 2019 | Featured, Grand Round Summaries

In this post, we will aim to review the literature looking at identifying clinical and historical features that can help differentiate stroke mimics from strokes. We will also discuss the safety of the administration of IV tPA to misdiagnosed stroke mimics. This post...
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